IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v461y2009i7264d10.1038_nature08402.html
   My bibliography  Save this article

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

Author

Listed:
  • Lorraine A. O’ Reilly

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Lin Tai

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Lily Lee

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Elizabeth A. Kruse

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    The University of Melbourne, Parkville, Victoria 3010, Australia)

  • Stephanie Grabow

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    The University of Melbourne, Parkville, Victoria 3010, Australia)

  • W. Douglas Fairlie

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Nicole M. Haynes

    (Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia)

  • David M. Tarlinton

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Jian-Guo Zhang

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Gabrielle T. Belz

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Mark J. Smyth

    (Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia)

  • Philippe Bouillet

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Lorraine Robb

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Andreas Strasser

    (The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

Abstract

FasL's non-apoptotic functions The transmembrane protein known as FasL (Fas ligand) is a member of the tumour necrosis factor family with an important role in immune regulation. The binding of FasL with its receptor induces apoptosis, but it has not been clear how important cell death is in FasL's cellular functions. Experiments using gene-targeted mice that either lack secreted FasL but express normal levels of membrane-bound FasL or, that lack membrane-bound FasL but can still produce secreted FasL, show that soluble FasL promotes autoimmunity and tumorigenesis through mechanisms that do not involve apoptosis.

Suggested Citation

  • Lorraine A. O’ Reilly & Lin Tai & Lily Lee & Elizabeth A. Kruse & Stephanie Grabow & W. Douglas Fairlie & Nicole M. Haynes & David M. Tarlinton & Jian-Guo Zhang & Gabrielle T. Belz & Mark J. Smyth & P, 2009. "Membrane-bound Fas ligand only is essential for Fas-induced apoptosis," Nature, Nature, vol. 461(7264), pages 659-663, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7264:d:10.1038_nature08402
    DOI: 10.1038/nature08402
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08402
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08402?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:461:y:2009:i:7264:d:10.1038_nature08402. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.