IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v461y2009i7263d10.1038_nature08362.html
   My bibliography  Save this article

Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling

Author

Listed:
  • Masaaki Torii

    (Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Keck School of Medicine of USC, Los Angeles, California 90089, USA)

  • Kazue Hashimoto-Torii

    (Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA)

  • Pat Levitt

    (Keck School of Medicine of USC, Los Angeles, California 90089, USA)

  • Pasko Rakic

    (Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA)

Abstract

Neural development: of columns and clones A feature of the development of the cerebral cortex in the embryo is the migration of neocortical excitatory neurons along radial glial fibres. Less studied than this movement along columnar structures is the regulation and outcome of the tangential mixing of clonal populations of neural progenitors migrating from their origin and encountering those travelling from other proliferative units. Rakic and colleagues report evidence that EphA/ephrin-A signalling modulates this mixing of populations during circuit development. In the absence of ephrin-A, tangential migration is disrupted, leading to impaired lateral dispersion and abnormal columnar organization. Aberrant columnar organization is thought to cause functional impairment within circuits.

Suggested Citation

  • Masaaki Torii & Kazue Hashimoto-Torii & Pat Levitt & Pasko Rakic, 2009. "Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling," Nature, Nature, vol. 461(7263), pages 524-528, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7263:d:10.1038_nature08362
    DOI: 10.1038/nature08362
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08362
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08362?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:461:y:2009:i:7263:d:10.1038_nature08362. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.