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Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs

Author

Listed:
  • Martin Zofall

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health Bethesda)

  • Tamás Fischer

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health Bethesda)

  • Ke Zhang

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health Bethesda)

  • Ming Zhou

    (Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA)

  • Bowen Cui

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health Bethesda)

  • Timothy D. Veenstra

    (Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA)

  • Shiv I. S. Grewal

    (Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health Bethesda)

Abstract

Antisense RNAs suppressed by histone H2A.Z Unregulated transcription of antisense RNAs is potentially deleterious to a cell because sense–antisense pairing could affect gene expression. In this study, Zofall et al. examine how antisense transcription is held in check in fission yeast. They find that the variant histone H2A.Z, which localizes to the 5′ ends of genes, cooperates with heterochromatin and RNA interference factors to mediate suppression of antisense transcription.

Suggested Citation

  • Martin Zofall & Tamás Fischer & Ke Zhang & Ming Zhou & Bowen Cui & Timothy D. Veenstra & Shiv I. S. Grewal, 2009. "Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs," Nature, Nature, vol. 461(7262), pages 419-422, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7262:d:10.1038_nature08321
    DOI: 10.1038/nature08321
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