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Chromosome crosstalk in three dimensions

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  • Anita Göndör

    (Tumor and Cell Biology
    Karolinska Institute)

  • Rolf Ohlsson

    (Tumor and Cell Biology
    Karolinska Institute)

Abstract

The genome forms extensive and dynamic physical interactions with itself in the form of chromosome loops and bridges, thus exploring the three-dimensional space of the nucleus. It is now possible to examine these interactions at the molecular level, and we have gained glimpses of their functional implications. Chromosomal interactions can contribute to the silencing and activation of genes within the three-dimensional context of the nuclear architecture. Technical advances in detecting these interactions contribute to our understanding of the functional organization of the genome, as well as its adaptive plasticity in response to environmental changes during development and disease.

Suggested Citation

  • Anita Göndör & Rolf Ohlsson, 2009. "Chromosome crosstalk in three dimensions," Nature, Nature, vol. 461(7261), pages 212-217, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7261:d:10.1038_nature08453
    DOI: 10.1038/nature08453
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