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Implications of chimaeric non-co-linear transcripts

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  • Thomas R. Gingeras

    (Cold Spring Harbor Laboratory)

Abstract

Deep sequencing of 'transcriptomes' — the collection of all RNA transcripts produced at a given time — from worms to humans reveals that some transcripts are composed of sequence segments that are not co-linear, with pieces of sequence coming from distant regions of DNA, even different chromosomes. Some of these 'chimaeric' transcripts are formed by genetic rearrangements, but others arise during post-transcriptional events. The 'trans-splicing' process in lower eukaryotes is well understood, but events in higher eukaryotes are not. The existence of such chimaeric RNAs has far-reaching implications for the potential information content of genomes and the way it is arranged.

Suggested Citation

  • Thomas R. Gingeras, 2009. "Implications of chimaeric non-co-linear transcripts," Nature, Nature, vol. 461(7261), pages 206-211, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7261:d:10.1038_nature08452
    DOI: 10.1038/nature08452
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