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Co-translational mRNA decay in Saccharomyces cerevisiae

Author

Listed:
  • Wenqian Hu

    (Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA)

  • Thomas J. Sweet

    (Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA)

  • Sangpen Chamnongpol

    (Affymetrix Inc., 26111 Miles Road, Cleveland, Ohio 44128, USA)

  • Kristian E. Baker

    (Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA)

  • Jeff Coller

    (Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio 44106, USA)

Abstract

The rates of RNA decay and transcription determine the steady-state levels of all messenger RNA and both can be subject to regulation. Although the details of transcriptional regulation are becoming increasingly understood, the mechanism(s) controlling mRNA decay remain unclear. In yeast, a major pathway of mRNA decay begins with deadenylation followed by decapping and 5′–3′ exonuclease digestion. Importantly, it is hypothesized that ribosomes must be removed from mRNA before transcripts are destroyed. Contrary to this prediction, here we show that decay takes place while mRNAs are associated with actively translating ribosomes. The data indicate that dissociation of ribosomes from mRNA is not a prerequisite for decay and we suggest that the 5′–3′ polarity of mRNA degradation has evolved to ensure that the last translocating ribosome can complete translation.

Suggested Citation

  • Wenqian Hu & Thomas J. Sweet & Sangpen Chamnongpol & Kristian E. Baker & Jeff Coller, 2009. "Co-translational mRNA decay in Saccharomyces cerevisiae," Nature, Nature, vol. 461(7261), pages 225-229, September.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7261:d:10.1038_nature08265
    DOI: 10.1038/nature08265
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    Cited by:

    1. Tin-Lok Wong & Jia-Jian Loh & Shixun Lu & Helen H. N. Yan & Hoi Cheong Siu & Ren Xi & Dessy Chan & Max J. F. Kam & Lei Zhou & Man Tong & John A. Copland & Leilei Chen & Jing-Ping Yun & Suet Yi Leung &, 2023. "ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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