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Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

Author

Listed:
  • Benjamin Yazdanpanah

    (Institute for Medical Microbiology, Immunology and Hygiene,
    Center of Molecular Medicine Cologne,)

  • Katja Wiegmann

    (Institute for Medical Microbiology, Immunology and Hygiene,)

  • Vladimir Tchikov

    (Institute for Immunology, University of Kiel)

  • Oleg Krut

    (Institute for Medical Microbiology, Immunology and Hygiene,
    Center of Molecular Medicine Cologne,)

  • Carola Pongratz

    (Institute for Medical Microbiology, Immunology and Hygiene,)

  • Michael Schramm

    (Institute for Medical Microbiology, Immunology and Hygiene,)

  • Andre Kleinridders

    (Institute for Genetics, University of Cologne, 50935 Cologne, Germany)

  • Thomas Wunderlich

    (Institute for Genetics, University of Cologne, 50935 Cologne, Germany)

  • Hamid Kashkar

    (Institute for Medical Microbiology, Immunology and Hygiene,
    Center of Molecular Medicine Cologne,
    Cologne cluster of excellence on cellular stress responses in aging-associated diseases, (CECAD), 50674 Cologne, Germany)

  • Olaf Utermöhlen

    (Institute for Medical Microbiology, Immunology and Hygiene,
    Center of Molecular Medicine Cologne,)

  • Jens C. Brüning

    (Center of Molecular Medicine Cologne,
    Institute for Genetics, University of Cologne, 50935 Cologne, Germany
    Cologne cluster of excellence on cellular stress responses in aging-associated diseases, (CECAD), 50674 Cologne, Germany)

  • Stefan Schütze

    (Institute for Immunology, University of Kiel)

  • Martin Krönke

    (Institute for Medical Microbiology, Immunology and Hygiene,
    Center of Molecular Medicine Cologne,
    Cologne cluster of excellence on cellular stress responses in aging-associated diseases, (CECAD), 50674 Cologne, Germany)

Abstract

Riboflavin kinase: linking TNF receptor to NAPDH oxidation Riboflavin kinase has been identified as a novel interacting partner for the death domain of receptor-1 for tumour necrosis factor (TNF-R1). It is required to recruit to and functionally couple p22phox to TNF-R1. As p22phox is the catalytic subunit of NADPH oxidases Nox1–4, this has general implications for TNF-induced NADPH oxidase activation and reactive oxygen species (ROS) production by many cell types and tissues. These findings may also be of relevance to the role of ROS in host defence and in the pathogenesis of many diseases including inflammation or atherosclerosis.

Suggested Citation

  • Benjamin Yazdanpanah & Katja Wiegmann & Vladimir Tchikov & Oleg Krut & Carola Pongratz & Michael Schramm & Andre Kleinridders & Thomas Wunderlich & Hamid Kashkar & Olaf Utermöhlen & Jens C. Brüning & , 2009. "Riboflavin kinase couples TNF receptor 1 to NADPH oxidase," Nature, Nature, vol. 460(7259), pages 1159-1163, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7259:d:10.1038_nature08206
    DOI: 10.1038/nature08206
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