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In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

Author

Listed:
  • Yasushi Itoh

    (Shiga University of Medical Science, Ohtsu, Shiga 520-2192, Japan)

  • Kyoko Shinya

    (Kobe University)

  • Maki Kiso

    (Institute of Medical Science, University of Tokyo)

  • Tokiko Watanabe

    (University of Wisconsin-Madison, Madison, Wisconsin 53711, USA)

  • Yoshihiro Sakoda

    (Graduate School of Veterinary Medicine, Hokkaido University)

  • Masato Hatta

    (University of Wisconsin-Madison, Madison, Wisconsin 53711, USA)

  • Yukiko Muramoto

    (ERATO Infection-Induced Host Responses Project)

  • Daisuke Tamura

    (Institute of Medical Science, University of Tokyo)

  • Yuko Sakai-Tagawa

    (Institute of Medical Science, University of Tokyo)

  • Takeshi Noda

    (International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo)

  • Saori Sakabe

    (Institute of Medical Science, University of Tokyo)

  • Masaki Imai

    (University of Wisconsin-Madison, Madison, Wisconsin 53711, USA)

  • Yasuko Hatta

    (University of Wisconsin-Madison, Madison, Wisconsin 53711, USA)

  • Shinji Watanabe

    (University of Wisconsin-Madison, Madison, Wisconsin 53711, USA)

  • Chengjun Li

    (University of Wisconsin-Madison, Madison, Wisconsin 53711, USA)

  • Shinya Yamada

    (Institute of Medical Science, University of Tokyo)

  • Ken Fujii

    (Institute of Medical Science, University of Tokyo)

  • Shin Murakami

    (Institute of Medical Science, University of Tokyo)

  • Hirotaka Imai

    (Institute of Medical Science, University of Tokyo)

  • Satoshi Kakugawa

    (Institute of Medical Science, University of Tokyo)

  • Mutsumi Ito

    (Institute of Medical Science, University of Tokyo)

  • Ryo Takano

    (Institute of Medical Science, University of Tokyo)

  • Kiyoko Iwatsuki-Horimoto

    (Institute of Medical Science, University of Tokyo)

  • Masayuki Shimojima

    (Institute of Medical Science, University of Tokyo)

  • Taisuke Horimoto

    (Institute of Medical Science, University of Tokyo)

  • Hideo Goto

    (Institute of Medical Science, University of Tokyo)

  • Kei Takahashi

    (Institute of Medical Science, University of Tokyo)

  • Akiko Makino

    (Kobe University)

  • Hirohito Ishigaki

    (Shiga University of Medical Science, Ohtsu, Shiga 520-2192, Japan)

  • Misako Nakayama

    (Shiga University of Medical Science, Ohtsu, Shiga 520-2192, Japan)

  • Masatoshi Okamatsu

    (Graduate School of Veterinary Medicine, Hokkaido University)

  • Kazuo Takahashi

    (Osaka Prefectural Institute of Public Health)

  • David Warshauer

    (Wisconsin State Laboratory of Hygiene, Madison, Wisconsin 53706, USA)

  • Peter A. Shult

    (Wisconsin State Laboratory of Hygiene, Madison, Wisconsin 53706, USA)

  • Reiko Saito

    (Niigata University, Graduate School of Medical and Dental Sciences)

  • Hiroshi Suzuki

    (Niigata University, Graduate School of Medical and Dental Sciences)

  • Yousuke Furuta

    (Toyama Chemical Co., Ltd.)

  • Makoto Yamashita

    (Daiichi Sankyo Co Ltd, Shinagawa, Tokyo 140–8710, Japan)

  • Keiko Mitamura

    (Eiju General Hospital)

  • Kunio Nakano

    (Eiju General Hospital)

  • Morio Nakamura

    (Eiju General Hospital)

  • Rebecca Brockman-Schneider

    (School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA)

  • Hiroshi Mitamura

    (Mitamura Clinic)

  • Masahiko Yamazaki

    (Zama Children’s Clinic)

  • Norio Sugaya

    (Keiyu Hospital)

  • M. Suresh

    (University of Wisconsin-Madison, Madison, Wisconsin 53711, USA)

  • Makoto Ozawa

    (University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
    International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo)

  • Gabriele Neumann

    (University of Wisconsin-Madison, Madison, Wisconsin 53711, USA)

  • James Gern

    (School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA)

  • Hiroshi Kida

    (Graduate School of Veterinary Medicine, Hokkaido University)

  • Kazumasa Ogasawara

    (Shiga University of Medical Science, Ohtsu, Shiga 520-2192, Japan)

  • Yoshihiro Kawaoka

    (Kobe University
    Institute of Medical Science, University of Tokyo
    University of Wisconsin-Madison, Madison, Wisconsin 53711, USA
    ERATO Infection-Induced Host Responses Project)

Abstract

Pandemic virus characterized Analysis of a series of clinical isolates of the swine-origin H1N1 influenza virus reveals that in mammalian models (mice, ferrets and macaques) the current pandemic virus is associated with more severe disease than a seasonal H1N1 strain. The viruses can also infect pigs but do not cause clinical signs. All antivirus drugs tested, including Tamiflu, were effective in cell culture against the new virus, lending support to the use of these compounds as a first line of defence against the pandemic.

Suggested Citation

  • Yasushi Itoh & Kyoko Shinya & Maki Kiso & Tokiko Watanabe & Yoshihiro Sakoda & Masato Hatta & Yukiko Muramoto & Daisuke Tamura & Yuko Sakai-Tagawa & Takeshi Noda & Saori Sakabe & Masaki Imai & Yasuko , 2009. "In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses," Nature, Nature, vol. 460(7258), pages 1021-1025, August.
  • Handle: RePEc:nat:nature:v:460:y:2009:i:7258:d:10.1038_nature08260
    DOI: 10.1038/nature08260
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