IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v460y2009i7258d10.1038_nature08229.html
   My bibliography  Save this article

XIAP discriminates between type I and type II FAS-induced apoptosis

Author

Listed:
  • Philipp J. Jost

    (The Walter and Eliza Hall Institute of Medical Research,)

  • Stephanie Grabow

    (The Walter and Eliza Hall Institute of Medical Research,
    Melbourne University, Parkville, Victoria 3050, Australia)

  • Daniel Gray

    (The Walter and Eliza Hall Institute of Medical Research,)

  • Mark D. McKenzie

    (Melbourne University, Parkville, Victoria 3050, Australia
    St Vincent’s Institute of Medical Research, Fitzroy, Victoria 3065, Australia)

  • Ueli Nachbur

    (Institute of Biochemistry, LaTrobe University, Bundoora, Victoria 3086, Australia)

  • David C. S. Huang

    (The Walter and Eliza Hall Institute of Medical Research,)

  • Philippe Bouillet

    (The Walter and Eliza Hall Institute of Medical Research,)

  • Helen E. Thomas

    (St Vincent’s Institute of Medical Research, Fitzroy, Victoria 3065, Australia)

  • Christoph Borner

    (Institute of Molecular Medicine and Cell Research, Centre for Biochemistry and Molecular Cell Research, Freiburg, D79104, Germany)

  • John Silke

    (Institute of Biochemistry, LaTrobe University, Bundoora, Victoria 3086, Australia)

  • Andreas Strasser

    (The Walter and Eliza Hall Institute of Medical Research,)

  • Thomas Kaufmann

    (The Walter and Eliza Hall Institute of Medical Research,
    Present address: Institute of Pharmacology, University of Bern, Bern, CH-3010, Switzerland.)

Abstract

Divergent routes to cell death One of the current problems in cell death research is to understand why distinct cell types (type I versus type II cells) differ so markedly in the mechanisms by which the 'death receptor' FAS triggers their apoptosis. Type I cells die by FAS-induced activation of caspase-8 and downstream effector caspases, leading a quick demise; type II cells, however, have to amplify the caspase cascade through caspase-8-mediated activation of the 'death agonist' BID, and subsequent activation of caspase-9. Jost et al. now show that the inhibitor of apoptosis, XIAP, makes all the difference for these cells: without XIAP a type II cell dies just like any cell type I. The authors suggest that IAP inhibitors should be used with caution in cancer patients with underlying liver conditions since they might unintentionally sensitize non-target cells to die.

Suggested Citation

  • Philipp J. Jost & Stephanie Grabow & Daniel Gray & Mark D. McKenzie & Ueli Nachbur & David C. S. Huang & Philippe Bouillet & Helen E. Thomas & Christoph Borner & John Silke & Andreas Strasser & Thomas, 2009. "XIAP discriminates between type I and type II FAS-induced apoptosis," Nature, Nature, vol. 460(7258), pages 1035-1039, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7258:d:10.1038_nature08229
    DOI: 10.1038/nature08229
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature08229
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature08229?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:460:y:2009:i:7258:d:10.1038_nature08229. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.