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A role for Lin28 in primordial germ-cell development and germ-cell malignancy

Author

Listed:
  • Jason A. West

    (Children’s Hospital Boston and the Dana-Farber Cancer Institute
    Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA)

  • Srinivas R. Viswanathan

    (Children’s Hospital Boston and the Dana-Farber Cancer Institute
    Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA)

  • Akiko Yabuuchi

    (Children’s Hospital Boston and the Dana-Farber Cancer Institute
    Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA)

  • Kerianne Cunniff

    (Children’s Hospital Boston and the Dana-Farber Cancer Institute
    Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA)

  • Ayumu Takeuchi

    (Children’s Hospital Boston and the Dana-Farber Cancer Institute
    Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA)

  • In-Hyun Park

    (Children’s Hospital Boston and the Dana-Farber Cancer Institute
    Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA)

  • Julia E. Sero

    (Children’s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Hao Zhu

    (Children’s Hospital Boston and the Dana-Farber Cancer Institute
    Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA)

  • Antonio Perez-Atayde

    (Children’s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA)

  • A. Lindsay Frazier

    (Children’s Hospital Boston and the Dana-Farber Cancer Institute
    Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • M. Azim Surani

    (Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK)

  • George Q. Daley

    (Children’s Hospital Boston and the Dana-Farber Cancer Institute
    Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Manton Center for Orphan Disease Research, Boston, Massachusetts 02115, USA
    Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA)

Abstract

Reproductive cell formation An RNA interference screen of 30 gene candidates has identified Lin28, a negative regulator of let-7 microRNA processing, as a potentially key regulator of primordial germ cell development, the process in the developing embryo that selects the cells destined to produce sperm and eggs. In addition, Lin28 levels are elevated in primary human germ cell tumours, suggesting that it may also be implicated in germ cell malignancy.

Suggested Citation

  • Jason A. West & Srinivas R. Viswanathan & Akiko Yabuuchi & Kerianne Cunniff & Ayumu Takeuchi & In-Hyun Park & Julia E. Sero & Hao Zhu & Antonio Perez-Atayde & A. Lindsay Frazier & M. Azim Surani & Geo, 2009. "A role for Lin28 in primordial germ-cell development and germ-cell malignancy," Nature, Nature, vol. 460(7257), pages 909-913, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7257:d:10.1038_nature08210
    DOI: 10.1038/nature08210
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