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Switch in FGF signalling initiates glial differentiation in the Drosophila eye

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  • Sigrídur Rut Franzdóttir

    (Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany
    Present address: Biomedical Center, University of Iceland, 101 Reykjavik, Iceland.)

  • Daniel Engelen

    (Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany)

  • Yeliz Yuva-Aydemir

    (Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany)

  • Imke Schmidt

    (Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany)

  • Annukka Aho

    (Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany)

  • Christian Klämbt

    (Institut für Neurobiologie, Universität Münster, Badestr. 9, D-48149 Münster, Germany)

Abstract

FGF signalling and glial regulation Glial cells play essential roles at all steps in the building and wiring of nervous systems. Franzdóttir et al. now identify proteins of the FGF-8 family secreted first by glial and then by neuronal cells during eye development in the fruit fly. These proteins respectively control the initial glial-cell proliferation and migration, then the switch to terminal glia differentiation and their wrapping and insulation of nerves. As the signalling pathways implicated have been conserved during evolution, genetics tools available in Drosophila should stimulate research on human neurological disorders involving glia.

Suggested Citation

  • Sigrídur Rut Franzdóttir & Daniel Engelen & Yeliz Yuva-Aydemir & Imke Schmidt & Annukka Aho & Christian Klämbt, 2009. "Switch in FGF signalling initiates glial differentiation in the Drosophila eye," Nature, Nature, vol. 460(7256), pages 758-761, August.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7256:d:10.1038_nature08167
    DOI: 10.1038/nature08167
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