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Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz

Author

Listed:
  • Brandon F. Keele

    (Department of Medicine,
    Present address: The AIDS and Cancer Virus Program, Science Applications International Corporation-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.)

  • James Holland Jones

    (Stanford University, Stanford, California 94305, USA)

  • Karen A. Terio

    (University of Illinois Zoological Pathology Program, Maywood, Illinois 60153, USA)

  • Jacob D. Estes

    (The AIDS and Cancer Virus Program, Science Applications International Corporation-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland 21702, USA)

  • Rebecca S. Rudicell

    (Department of Microbiology,)

  • Michael L. Wilson

    (University of Minnesota, Minneapolis, Minnesota 55455, USA
    Jane Goodall Institute’s Center for Primate Studies, Evolution and Behavior, University of Minnesota, St Paul, Minnesota 55108, USA)

  • Yingying Li

    (Department of Medicine,)

  • Gerald H. Learn

    (Department of Medicine,)

  • T. Mark Beasley

    (University of Alabama at Birmingham, Birmingham, Alabama 35294, USA)

  • Joann Schumacher-Stankey

    (Jane Goodall Institute’s Center for Primate Studies, Evolution and Behavior, University of Minnesota, St Paul, Minnesota 55108, USA)

  • Emily Wroblewski

    (Jane Goodall Institute’s Center for Primate Studies, Evolution and Behavior, University of Minnesota, St Paul, Minnesota 55108, USA)

  • Anna Mosser

    (Gombe Stream Research Centre, The Jane Goodall Institute)

  • Jane Raphael

    (Gombe Stream Research Centre, The Jane Goodall Institute)

  • Shadrack Kamenya

    (Gombe Stream Research Centre, The Jane Goodall Institute)

  • Elizabeth V. Lonsdorf

    (The Lester E. Fisher Center for the Study and Conservation of Apes and,)

  • Dominic A. Travis

    (Lincoln Park Zoo, Chicago, Illinois 60614, USA)

  • Titus Mlengeya

    (Tanzania National Parks)

  • Michael J. Kinsel

    (University of Illinois Zoological Pathology Program, Maywood, Illinois 60153, USA)

  • James G. Else

    (Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA)

  • Guido Silvestri

    (University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA)

  • Jane Goodall

    (The Jane Goodall Institute, Arlington, Virginia 22203, USA)

  • Paul M. Sharp

    (Institute of Evolutionary Biology, University of Edinburgh)

  • George M. Shaw

    (Department of Medicine,)

  • Anne E. Pusey

    (Jane Goodall Institute’s Center for Primate Studies, Evolution and Behavior, University of Minnesota, St Paul, Minnesota 55108, USA)

  • Beatrice H. Hahn

    (Department of Medicine,
    Department of Microbiology,)

Abstract

'AIDS' in chimpanzees There are more than 40 different types of simian immunodeficiency virus (SIV) infecting African primates, two of which crossed the species barrier to produce the AIDS viruses HIV-1 and HIV-2 in humans. Now a comprehensive natural history study of free-ranging chimpanzees in Gombe National Park has overturned a common assumption about SIVcpz, the precursor of HIV-1. It has been widely assumed that all SIVs are non-pathogenic in their natural hosts. But this new study, which followed 94 chimpanzees for over 9 years, shows that SIVcpz infection is associated with AIDS-like signs in chimpanzees, including a more than 10-fold increase in mortality risk, reduced fertility and progressive CD4+ T-cell depletion. By comparing the disease-causing mechanisms of these related retroviruses in humans and chimpanzees it may be possible to identify viral and host factors of interest to developers of drugs and vaccines for the prevention and treatment of HIV infection.

Suggested Citation

  • Brandon F. Keele & James Holland Jones & Karen A. Terio & Jacob D. Estes & Rebecca S. Rudicell & Michael L. Wilson & Yingying Li & Gerald H. Learn & T. Mark Beasley & Joann Schumacher-Stankey & Emily , 2009. "Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz," Nature, Nature, vol. 460(7254), pages 515-519, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7254:d:10.1038_nature08200
    DOI: 10.1038/nature08200
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