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Modulation of microRNA processing by p53

Author

Listed:
  • Hiroshi I. Suzuki

    (Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

  • Kaoru Yamagata

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
    ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchisi, Saitama 332-0012, Japan)

  • Koichi Sugimoto

    (Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan)

  • Takashi Iwamoto

    (College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan)

  • Shigeaki Kato

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
    ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchisi, Saitama 332-0012, Japan)

  • Kohei Miyazono

    (Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan)

Abstract

Link between p53 and miRNA The p53 tumour suppressor is a well known transcriptional activator with many growth suppressive targets. Disruption of p53 function is a fundamental event in the development of most cancers. MicroRNAs (miRNAs) have emerged as significant factors in tumour suppression, and in this work an unexpected link between p53 and miRNAs has been found. In an interaction that is independent of its role in regulating transcription, p53 enhances post-transcriptional maturation of several growth-suppressive miRNAs, including miR-16-1, miR-143 and miR-145, in response to DNA damage. This suggests that p53's ability to modulate miRNA biogenesis could contribute to its oncogenic potential.

Suggested Citation

  • Hiroshi I. Suzuki & Kaoru Yamagata & Koichi Sugimoto & Takashi Iwamoto & Shigeaki Kato & Kohei Miyazono, 2009. "Modulation of microRNA processing by p53," Nature, Nature, vol. 460(7254), pages 529-533, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7254:d:10.1038_nature08199
    DOI: 10.1038/nature08199
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    Cited by:

    1. Guangwen Long & Feng Wang & Quanlu Duan & Shenglan Yang & Fuqiong Chen & Wei Gong & Xu Yang & Yan Wang & Chen Chen & Dao Wen Wang, 2012. "Circulating miR-30a, miR-195 and let-7b Associated with Acute Myocardial Infarction," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-8, December.
    2. Dario Dattilo & Gaia Di Timoteo & Adriano Setti & Andrea Giuliani & Giovanna Peruzzi & Manuel Beltran Nebot & Alvaro Centrón-Broco & Davide Mariani & Chiara Mozzetta & Irene Bozzoni, 2023. "The m6A reader YTHDC1 and the RNA helicase DDX5 control the production of rhabdomyosarcoma-enriched circRNAs," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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