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Regulation of the innate immune response by threonine-phosphatase of Eyes absent

Author

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  • Yasutaka Okabe

    (Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Kyoto 606-8501, Japan
    Solution Oriented Research for Science and Technology, and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation
    Present address: Department of Immunobiology, Yale University School of Medicine, TAC S-669, 300 Cedar Street, New Haven, Connecticut 06510, USA.)

  • Teruyuki Sano

    (Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Kyoto 606-8501, Japan)

  • Shigekazu Nagata

    (Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Kyoto 606-8501, Japan
    Solution Oriented Research for Science and Technology, and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation)

Abstract

EYA4 protein and innate immunity EYA4 (Eyes absent 4), was originally identified as a Drosophila transcription factor regulating eye development, and four EYA family proteins have since been identified in mammals. Here it is shown that the threonine phosphatase activity of EYA4 stimulates the innate immune response to apoptotic-cell-derived undigested DNA and enhances the response against cytosolic double-stranded RNA.

Suggested Citation

  • Yasutaka Okabe & Teruyuki Sano & Shigekazu Nagata, 2009. "Regulation of the innate immune response by threonine-phosphatase of Eyes absent," Nature, Nature, vol. 460(7254), pages 520-524, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7254:d:10.1038_nature08138
    DOI: 10.1038/nature08138
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