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CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

Author

Listed:
  • Ivan Zanoni

    (University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy)

  • Renato Ostuni

    (University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy)

  • Giusy Capuano

    (University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy)

  • Maddalena Collini

    (University of Milano-Bicocca, Piazza della Scienza 3, 20126 Milan, Italy)

  • Michele Caccia

    (University of Milano-Bicocca, Piazza della Scienza 3, 20126 Milan, Italy)

  • Antonella Ellena Ronchi

    (University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy)

  • Marcella Rocchetti

    (University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy)

  • Francesca Mingozzi

    (University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy)

  • Maria Foti

    (University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy)

  • Giuseppe Chirico

    (University of Milano-Bicocca, Piazza della Scienza 3, 20126 Milan, Italy)

  • Barbara Costa

    (University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy)

  • Antonio Zaza

    (University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy)

  • Paola Ricciardi-Castagnoli

    (University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Present address: Singapore Immunology Network (SIgN), Biomedical Sciences Institutes, Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, IMMUNOS, 138648, Singapore.)

  • Francesca Granucci

    (University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy)

Abstract

CD14 in apoptosis This study defines a previously unknown specific role for CD14, a molecule that, in conjunction with other receptors, recognizes the lipopolysaccharide (LPS) of bacterial cell wall. CD14 is shown to regulate dendritic cell apoptosis after LPS stimulation via a PLC-γ2–Ca2+–NFAT-dependent pathway. This finding significantly advances the knowledge of the molecular events occurring during the initial phases of defence to bacterial infections.

Suggested Citation

  • Ivan Zanoni & Renato Ostuni & Giusy Capuano & Maddalena Collini & Michele Caccia & Antonella Ellena Ronchi & Marcella Rocchetti & Francesca Mingozzi & Maria Foti & Giuseppe Chirico & Barbara Costa & A, 2009. "CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation," Nature, Nature, vol. 460(7252), pages 264-268, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7252:d:10.1038_nature08118
    DOI: 10.1038/nature08118
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