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T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

Author

Listed:
  • Greta Guarda

    (University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland)

  • Catherine Dostert

    (University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland)

  • Francesco Staehli

    (University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland)

  • Katrin Cabalzar

    (University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland)

  • Rosa Castillo

    (University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland)

  • Aubry Tardivel

    (University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland)

  • Pascal Schneider

    (University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland)

  • Jürg Tschopp

    (University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland)

Abstract

Innate immunity: keeping control The innate immunity response must be kept under tight control, since a disproportionate response could be harmful to host tissues as well as to the invading pathogen. Guarda et al. this week report a role for activated T lymphocytes in exerting that control. Effector and memory CD4+ T cells are shown to inhibit NLRP1 and NLRP3 inflammasome activity

Suggested Citation

  • Greta Guarda & Catherine Dostert & Francesco Staehli & Katrin Cabalzar & Rosa Castillo & Aubry Tardivel & Pascal Schneider & Jürg Tschopp, 2009. "T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes," Nature, Nature, vol. 460(7252), pages 269-273, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7252:d:10.1038_nature08100
    DOI: 10.1038/nature08100
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