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Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages

Author

Listed:
  • Lei Bu

    (Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA)

  • Xin Jiang

    (Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA)

  • Silvia Martin-Puig

    (Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA)

  • Leslie Caron

    (Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA)

  • Shenjun Zhu

    (Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • Ying Shao

    (Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • Drucilla J. Roberts

    (Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • Paul L. Huang

    (Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA)

  • Ibrahim J. Domian

    (Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA)

  • Kenneth R. Chien

    (Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA)

Abstract

ISL1 progenitors are all heart Recent studies in mice identified multipotent embryonic ISL1+ (Islet 1 expressing) progenitor cells as capable of contributing to all of the major cell types in the heart. Human cardiogenesis is thought to involve more divergent pathways. Now a diverse set of human fetal ISL1+ cardiovascular progenitor populations with multipotent capability has been identified in the right atrium and outflow tract of the developing human heart. Transgenic and gene-targeting techniques applied to human embryonic stem cell lines show that purified populations of these primordial progenitors are capable of self-renewal and expansion prior to differentiation into the three major cell types in the heart — the cardiomyocytes, smooth muscle and endothelia. This has relevance for the production of human models for cardiovascular disease and potentially for human regenerative medicine.

Suggested Citation

  • Lei Bu & Xin Jiang & Silvia Martin-Puig & Leslie Caron & Shenjun Zhu & Ying Shao & Drucilla J. Roberts & Paul L. Huang & Ibrahim J. Domian & Kenneth R. Chien, 2009. "Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages," Nature, Nature, vol. 460(7251), pages 113-117, July.
    • Handle: RePEc:nat:nature:v:460:y:2009:i:7251:d:10.1038_nature08191
    DOI: 10.1038/nature08191
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