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Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

Author

Listed:
  • Lei Chen

    (MOE Key Laboratory of Bioinformatics, Tsinghua University)

  • Zhi-Hao Jiao

    (MOE Key Laboratory of Bioinformatics, Tsinghua University)

  • Li-Sha Zheng

    (Institute of Biophysics and Graduate University, Chinese Academy of Sciences)

  • Yuan-Yuan Zhang

    (MOE Key Laboratory of Bioinformatics, Tsinghua University)

  • Shu-Tao Xie

    (MOE Key Laboratory of Bioinformatics, Tsinghua University)

  • Zhi-Xin Wang

    (MOE Key Laboratory of Bioinformatics, Tsinghua University
    Institute of Biophysics and Graduate University, Chinese Academy of Sciences)

  • Jia-Wei Wu

    (MOE Key Laboratory of Bioinformatics, Tsinghua University)

Abstract

Molecular mechanism AMPK autoinhibition mechanism AMPK (AMP-activated protein kinase) senses cellular energy status to maintain a balance between ATP production and consumption and has important roles in regulating cell growth and proliferation. Here, crystal structures of kinase and autoinhibitory domains from yeast AMPK subunits, together with biochemical data, reveal a mechanism for AMPK autoinhibition and suggest a model for allosteric activation by AMP.

Suggested Citation

  • Lei Chen & Zhi-Hao Jiao & Li-Sha Zheng & Yuan-Yuan Zhang & Shu-Tao Xie & Zhi-Xin Wang & Jia-Wei Wu, 2009. "Structural insight into the autoinhibition mechanism of AMP-activated protein kinase," Nature, Nature, vol. 459(7250), pages 1146-1149, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7250:d:10.1038_nature08075
    DOI: 10.1038/nature08075
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