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Yurt, Coracle, Neurexin IV and the Na+,K+-ATPase form a novel group of epithelial polarity proteins

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  • Patrick Laprise

    (University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Present addresses: Laval University Cancer Research Center, CRCHUQ-Hôtel-Dieu de Québec, Québec City, Québec G1R 2J6,Canada (P.L.); Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA (S.B.).)

  • Kimberly M. Lau

    (University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Kathryn P. Harris

    (University of Toronto, Toronto, Ontario M5S 3G5, Canada)

  • Nancy F. Silva-Gagliardi

    (University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Sarah M. Paul

    (Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA)

  • Slobodan Beronja

    (University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Present addresses: Laval University Cancer Research Center, CRCHUQ-Hôtel-Dieu de Québec, Québec City, Québec G1R 2J6,Canada (P.L.); Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA (S.B.).)

  • Greg J. Beitel

    (Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA)

  • C. Jane McGlade

    (University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Ulrich Tepass

    (University of Toronto, Toronto, Ontario M5S 3G5, Canada)

Abstract

Cell polarity step-by-step Polarization of cells is critical for the development of multicellular organisms and defects in this process contribute to several diseases. Generation of epithelial cell polarity in Drosophila involves polarity proteins such as Crumbs and partitioning defective. This study reports the identification of a novel protein pathway — involving Yurt, Coracle, Neurexin IV and the sodium-potassium pump — that is important for polarity formation during early embryogenesis in Drosophila and appears to be conserved in mammalian cells. This work suggests that polarity maintenance is a multi-step process, with different protein complexes involved at each step.

Suggested Citation

  • Patrick Laprise & Kimberly M. Lau & Kathryn P. Harris & Nancy F. Silva-Gagliardi & Sarah M. Paul & Slobodan Beronja & Greg J. Beitel & C. Jane McGlade & Ulrich Tepass, 2009. "Yurt, Coracle, Neurexin IV and the Na+,K+-ATPase form a novel group of epithelial polarity proteins," Nature, Nature, vol. 459(7250), pages 1141-1145, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7250:d:10.1038_nature08067
    DOI: 10.1038/nature08067
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