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Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

Author

Listed:
  • Kwan-Hyuck Baek

    (Vascular Biology Program, Children’s Hospital Boston, Massachusetts 02115, USA)

  • Alexander Zaslavsky

    (Vascular Biology Program, Children’s Hospital Boston, Massachusetts 02115, USA)

  • Ryan C. Lynch

    (Vascular Biology Program, Children’s Hospital Boston, Massachusetts 02115, USA)

  • Carmella Britt

    (Vascular Biology Program, Children’s Hospital Boston, Massachusetts 02115, USA)

  • Yoshiaki Okada

    (Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA)

  • Richard J. Siarey

    (Physiology and Genetic, Neuroscience, Molecular and Cellular Biology Program, School of Medicine, Uniformed Services University of the Health Services, Bethesda, Maryland 20814, USA)

  • M. William Lensch

    (Children’s Hospital Boston, and Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA)

  • In-Hyun Park

    (Children’s Hospital Boston, and Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA)

  • Sam S. Yoon

    (Massachusetts General Hospital, Boston, Maryland 02114, USA)

  • Takashi Minami

    (Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, 153-8904, Japan)

  • Julie R. Korenberg

    (The University of Utah, Salt Lake City, Utah 84108, USA)

  • Judah Folkman

    (Vascular Biology Program, Children’s Hospital Boston, Massachusetts 02115, USA)

  • George Q. Daley

    (Children’s Hospital Boston, and Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA)

  • William C. Aird

    (Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA)

  • Zygmunt Galdzicki

    (Physiology and Genetic, Neuroscience, Molecular and Cellular Biology Program, School of Medicine, Uniformed Services University of the Health Services, Bethesda, Maryland 20814, USA)

  • Sandra Ryeom

    (Vascular Biology Program, Children’s Hospital Boston, Massachusetts 02115, USA)

Abstract

Down's syndrome and cancer Individuals with Down's syndrome are known to have a lower rate of certain solid cancers. New work from Baek et al. shows that a mouse model with an extra copy of the chromosome 21 gene Dscr1 (encoding Down syndrome critical region protein 1) exhibits decreased tumour growth due to reduced angiogenesis. They provide evidence that together with another chromosome 21 gene, Dyrk1a, a modest increase in Dscr1 expression limits angiogenesis by decreasing the activity of the calcineurin pathway. These data provide a mechanism for the reduced cancer incidence in Down's syndrome and identify the calcineurin signalling pathway, and its regulators DSCR1 and DYRK1A, as potential therapeutic targets in cancers arising in all individuals.

Suggested Citation

  • Kwan-Hyuck Baek & Alexander Zaslavsky & Ryan C. Lynch & Carmella Britt & Yoshiaki Okada & Richard J. Siarey & M. William Lensch & In-Hyun Park & Sam S. Yoon & Takashi Minami & Julie R. Korenberg & Jud, 2009. "Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1," Nature, Nature, vol. 459(7250), pages 1126-1130, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7250:d:10.1038_nature08062
    DOI: 10.1038/nature08062
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