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CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

Author

Listed:
  • Silvia Buonamici

    (Department of Pathology and New York University Cancer Institute,
    Helen L. and Martin S. Kimmel Stem Cell Center,)

  • Thomas Trimarchi

    (Department of Pathology and New York University Cancer Institute,
    Helen L. and Martin S. Kimmel Stem Cell Center,)

  • Maria Grazia Ruocco

    (Department of Pathology and New York University Cancer Institute,
    Program in Molecular Pathogenesis, Helen L. and Martin S. Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA)

  • Linsey Reavie

    (Department of Pathology and New York University Cancer Institute,
    Helen L. and Martin S. Kimmel Stem Cell Center,)

  • Severine Cathelin

    (Department of Pathology and New York University Cancer Institute,
    Helen L. and Martin S. Kimmel Stem Cell Center,)

  • Brenton G. Mar

    (Department of Pediatrics,)

  • Apostolos Klinakis

    (Columbia University Medical Center, New York, New York 10032, USA)

  • Yevgeniy Lukyanov

    (Department of Pathology and New York University Cancer Institute,)

  • Jen-Chieh Tseng

    (Department of Pathology and New York University Cancer Institute,)

  • Filiz Sen

    (Department of Pathology and New York University Cancer Institute,
    Helen L. and Martin S. Kimmel Stem Cell Center,)

  • Eric Gehrie

    (and the Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA)

  • Mengling Li

    (New York University Cancer Institute, New York, New York 10016, USA)

  • Elizabeth Newcomb

    (Department of Pathology and New York University Cancer Institute,)

  • Jiri Zavadil

    (Department of Pathology and New York University Cancer Institute,)

  • Daniel Meruelo

    (Department of Pathology and New York University Cancer Institute,)

  • Martin Lipp

    (Max-Delbrück-Center for Molecular Medicine)

  • Sherif Ibrahim

    (Department of Pathology and New York University Cancer Institute,)

  • Argiris Efstratiadis

    (Columbia University Medical Center, New York, New York 10032, USA)

  • David Zagzag

    (Department of Pathology and New York University Cancer Institute,)

  • Jonathan S. Bromberg

    (and the Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA)

  • Michael L. Dustin

    (Department of Pathology and New York University Cancer Institute,
    Program in Molecular Pathogenesis, Helen L. and Martin S. Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA)

  • Iannis Aifantis

    (Department of Pathology and New York University Cancer Institute,
    Helen L. and Martin S. Kimmel Stem Cell Center,)

Abstract

CNS infiltration in leukaemia T-cell acute leukaemias (T-ALL) often show central nervous system (CNS) infiltration that has to be treated aggressively. In most T-ALL cases, the Notch signalling pathway is constitutionally activated. Buonamici et al. now show that Notch signalling induces the expression of the cytokine receptor CCR7. CCR7 is shown to be responsible for the trafficking of T-ALL cells to the CNS; this appears to involve the expression of the CCR7 ligand CCL19 on brain endothelial cells. Targeting CCR7 may thus offer a therapeutic approach to prevent CNS relapse in T-ALL patients.

Suggested Citation

  • Silvia Buonamici & Thomas Trimarchi & Maria Grazia Ruocco & Linsey Reavie & Severine Cathelin & Brenton G. Mar & Apostolos Klinakis & Yevgeniy Lukyanov & Jen-Chieh Tseng & Filiz Sen & Eric Gehrie & Me, 2009. "CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia," Nature, Nature, vol. 459(7249), pages 1000-1004, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7249:d:10.1038_nature08020
    DOI: 10.1038/nature08020
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