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Mechanism of differential control of NMDA receptor activity by NR2 subunits

Author

Listed:
  • Marc Gielen

    (Laboratoire de Neurobiologie, École Normale Supérieure, CNRS, 46 rue d’Ulm, 75005 Paris, France)

  • Beth Siegler Retchless

    (University of Pittsburgh, A210 Langely Hall, Pittsburgh, Pennsylvania 15260, USA)

  • Laetitia Mony

    (Laboratoire de Neurobiologie, École Normale Supérieure, CNRS, 46 rue d’Ulm, 75005 Paris, France)

  • Jon W. Johnson

    (University of Pittsburgh, A210 Langely Hall, Pittsburgh, Pennsylvania 15260, USA)

  • Pierre Paoletti

    (Laboratoire de Neurobiologie, École Normale Supérieure, CNRS, 46 rue d’Ulm, 75005 Paris, France)

Abstract

NMDA receptors: NR2 subunits in control Members of the NMDA family of glutamate-gated ion channels, which play an important role in the control of synaptic plasticity and excitotoxic neuronal death in the brain, exhibit different opening probabilities and pharmacological profiles according to the NR2 subunit that they possess (NR2A-NR2D). Gielen et al. show that the degree of closure of the clamshell-like N-terminal domains of NR2 subunits determines this functional diversity.

Suggested Citation

  • Marc Gielen & Beth Siegler Retchless & Laetitia Mony & Jon W. Johnson & Pierre Paoletti, 2009. "Mechanism of differential control of NMDA receptor activity by NR2 subunits," Nature, Nature, vol. 459(7247), pages 703-707, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7247:d:10.1038_nature07993
    DOI: 10.1038/nature07993
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