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Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

Author

Listed:
  • Mara Compagno

    (Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,)

  • Wei Keat Lim

    (Joint Centers for Systems Biology,)

  • Adina Grunn

    (Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,)

  • Subhadra V. Nandula

    (Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
    Columbia University, New York, New York 10032, USA)

  • Manisha Brahmachary

    (Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,)

  • Qiong Shen

    (Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,)

  • Francesco Bertoni

    (Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI))

  • Maurilio Ponzoni

    (Pathology Unit, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute)

  • Marta Scandurra

    (Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI))

  • Andrea Califano

    (Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
    Joint Centers for Systems Biology,)

  • Govind Bhagat

    (Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
    Columbia University, New York, New York 10032, USA)

  • Amy Chadburn

    (Weill Medical College of Cornell University, New York, New York 10021, USA)

  • Riccardo Dalla-Favera

    (Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
    Columbia University, New York, New York 10032, USA
    Columbia University, New York, New York 10032, USA)

  • Laura Pasqualucci

    (Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
    Columbia University, New York, New York 10032, USA)

Abstract

A20 link to B-cell lymphoma Two groups report in this issue that A20 protein, a negative regulator of NF-κB signalling pathways, is frequently inactivated in patients with B-cell lymphoma. Kato et al. show that cells lacking the A20 gene generate tumours in immunodeficient mice, and that tumour formation is suppressed when the protein is re-expressed. Compagno et al. show that A20 is inactivated in around 30% of patients with B-cell lymphoma. Both groups show that A20 protein suppresses cell growth in vitro and prompts cells to commit suicide.

Suggested Citation

  • Mara Compagno & Wei Keat Lim & Adina Grunn & Subhadra V. Nandula & Manisha Brahmachary & Qiong Shen & Francesco Bertoni & Maurilio Ponzoni & Marta Scandurra & Andrea Califano & Govind Bhagat & Amy Cha, 2009. "Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma," Nature, Nature, vol. 459(7247), pages 717-721, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7247:d:10.1038_nature07968
    DOI: 10.1038/nature07968
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