IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v459y2009i7245d10.1038_nature07955.html
   My bibliography  Save this article

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Author

Listed:
  • Maximina H. Yun

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Kevin Hiom

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

Abstract

DNA repair: the chosen pathway Cells have two main DNA repair pathways, homologous recombination and end-joining, that were thought to function in different stages of the cell cycle. How the cell recognizes these stages and switches its predominant repair pathway is not well known. In this work, Maximina Yun and Kevin Hiom show that CtIP, a protein recently identified as a participant in the resection of broken DNA ends, serves to switch between these pathways. They show that as cells enter the cell stage that replicates DNA, CtIP undergoes a specific phosphorylation that recruits the breast cancer susceptibility protein, BRCA1, and this directs the cell to use homologous recombination.

Suggested Citation

  • Maximina H. Yun & Kevin Hiom, 2009. "CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle," Nature, Nature, vol. 459(7245), pages 460-463, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7245:d:10.1038_nature07955
    DOI: 10.1038/nature07955
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07955
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07955?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Martin Peterka & Nina Akrap & Songyuan Li & Sandra Wimberger & Pei-Pei Hsieh & Dmitrii Degtev & Burcu Bestas & Jack Barr & Stijn Plassche & Patricia Mendoza-Garcia & Saša Šviković & Grzegorz Sienski &, 2022. "Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Daipayan Banerjee & Kurt Langberg & Salar Abbas & Eric Odermatt & Praveen Yerramothu & Martin Volaric & Matthew A. Reidenbach & Kathy J. Krentz & C. Dustin Rubinstein & David L. Brautigan & Tarek Abba, 2021. "A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling," Nature Communications, Nature, vol. 12(1), pages 1-24, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:459:y:2009:i:7245:d:10.1038_nature07955. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.