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GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis

Author

Listed:
  • Ryoji Fujiki

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
    ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchisi, Saitama 332-0012, Japan)

  • Toshihiro Chikanishi

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
    ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchisi, Saitama 332-0012, Japan)

  • Waka Hashiba

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Hiroaki Ito

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Ichiro Takada

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Robert G. Roeder

    (Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA)

  • Hirochika Kitagawa

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Shigeaki Kato

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
    ERATO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchisi, Saitama 332-0012, Japan)

Abstract

GlcNAcylation of chromatin proteins in granulopoiesis The SET-domain-containing MLL proteins methylate histone H3 on lysine 4 and contribute to gene activation. Here, MLL5 is shown to associate in a complex with the retinoic acid receptor RARα and to be modified by O-linked β-N-acetylglucosamine (O-GlcNAc). Nuclear GlcNAcylation of MLL5 facilitates its activity as a co-activator of RARα target genes during granulopoiesis. This work points to an important role for GlcNAcylation in modifying chromatin proteins.

Suggested Citation

  • Ryoji Fujiki & Toshihiro Chikanishi & Waka Hashiba & Hiroaki Ito & Ichiro Takada & Robert G. Roeder & Hirochika Kitagawa & Shigeaki Kato, 2009. "GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis," Nature, Nature, vol. 459(7245), pages 455-459, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7245:d:10.1038_nature07954
    DOI: 10.1038/nature07954
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