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Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

Author

Listed:
  • Christopher W. Wilson

    (Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA)

  • Catherine T. Nguyen

    (Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA)

  • Miao-Hsueh Chen

    (Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA)

  • Jehn-Hsiahn Yang

    (Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Present address: Department of Obstetrics and Gynecology, College of Medicine and the Hospital, National Taiwan University, Taipei, Taiwan.)

  • Rhodora Gacayan

    (Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA)

  • Jie Huang

    (Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA)

  • Jau-Nian Chen

    (Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA)

  • Pao-Tien Chuang

    (Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA)

Abstract

Hedgehog signalling: the evolution of Fused Hedgehog (Hh) signalling is important in development and disease. In this study Pao-Tien Chuang and colleagues study the function and evolution of Fused (Fu), which is required for Hh signalling in Drosophila but not in mice. They find that the function of Fu has changed over evolution. In mice, Fu is required for the formation of motile cilia. In contrast, in zebrafish, Fu is required for both Hh signalling and cilia formation thus representing an evolutionary intermediate. This study reveals a novel pathway for cilia assembly and provides insight into the evolution of the Hh signalling cascade.

Suggested Citation

  • Christopher W. Wilson & Catherine T. Nguyen & Miao-Hsueh Chen & Jehn-Hsiahn Yang & Rhodora Gacayan & Jie Huang & Jau-Nian Chen & Pao-Tien Chuang, 2009. "Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis," Nature, Nature, vol. 459(7243), pages 98-102, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7243:d:10.1038_nature07883
    DOI: 10.1038/nature07883
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