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Germline-encoded amino acids in the αβ T-cell receptor control thymic selection

Author

Listed:
  • James P. Scott-Browne

    (National Jewish Health and University of Colorado Denver, Denver, Colorado 80206, USA)

  • Janice White

    (National Jewish Health and University of Colorado Denver, Denver, Colorado 80206, USA)

  • John W. Kappler

    (National Jewish Health and University of Colorado Denver, Denver, Colorado 80206, USA
    Howard Hughes Medical Institute,
    Department of Medicine,
    Department of Pharmacology,)

  • Laurent Gapin

    (National Jewish Health and University of Colorado Denver, Denver, Colorado 80206, USA)

  • Philippa Marrack

    (National Jewish Health and University of Colorado Denver, Denver, Colorado 80206, USA
    Howard Hughes Medical Institute,
    Department of Medicine,
    University of Colorado Denver, Aurora, Colorado 80220, USA)

Abstract

T-cell receptors An αβ T-cell response depends on the recognition of antigen plus major histocompatibility complex (MHC) proteins by its antigen receptor (TCR). Scott-Browne et al. present evidence that TCR genes encode inherent specificity for MHC molecules.

Suggested Citation

  • James P. Scott-Browne & Janice White & John W. Kappler & Laurent Gapin & Philippa Marrack, 2009. "Germline-encoded amino acids in the αβ T-cell receptor control thymic selection," Nature, Nature, vol. 458(7241), pages 1043-1046, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7241:d:10.1038_nature07812
    DOI: 10.1038/nature07812
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