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The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Author

Listed:
  • Alexandre Dias

    (Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMR 5233, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France)

  • Denis Bouvier

    (Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMR 5233, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France)

  • Thibaut Crépin

    (Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMR 5233, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France)

  • Andrew A. McCarthy

    (Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMR 5233, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France
    Grenoble Outstation, European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France)

  • Darren J. Hart

    (Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMR 5233, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France
    Grenoble Outstation, European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France)

  • Florence Baudin

    (Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMR 5233, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France)

  • Stephen Cusack

    (Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMR 5233, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France
    Grenoble Outstation, European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France)

  • Rob W. H. Ruigrok

    (Unit of Virus Host-Cell Interactions, UJF-EMBL-CNRS, UMR 5233, 6 rue Jules Horowitz, BP181, 38042 Grenoble Cedex 9, France)

Abstract

Avian flu virus polymerase The influenza virus RNA-dependent RNA polymerase, which contains three subunits (PA, PB1 and PB2), directs the replication and transcription of viral RNA inside the nuclei of infected cells. Two groups now report the crystal structure of the N terminus of the PA subunit of avian influenza virus. Structural comparison and mutational analysis show that the PA subunit contains an endonucleolytic cleavage site, an activity previously suspected to reside on the PB1 subunit. The PA endonuclease active site is highly conserved across influenza strains, making it a promising potential target for new anti-influenza drugs.

Suggested Citation

  • Alexandre Dias & Denis Bouvier & Thibaut Crépin & Andrew A. McCarthy & Darren J. Hart & Florence Baudin & Stephen Cusack & Rob W. H. Ruigrok, 2009. "The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit," Nature, Nature, vol. 458(7240), pages 914-918, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7240:d:10.1038_nature07745
    DOI: 10.1038/nature07745
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