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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

Author

Listed:
  • Chen Zhao

    (Department of Pharmacology and Cancer Biology,)

  • Alan Chen

    (Department of Pharmacology and Cancer Biology,)

  • Catriona H. Jamieson

    (Stem Cell Research Program, Moores UCSD Cancer Center La Jolla, California 92093, USA)

  • Mark Fereshteh

    (Department of Pharmacology and Cancer Biology,)

  • Annelie Abrahamsson

    (Stem Cell Research Program, Moores UCSD Cancer Center La Jolla, California 92093, USA)

  • Jordan Blum

    (Department of Pharmacology and Cancer Biology,)

  • Hyog Young Kwon

    (Department of Pharmacology and Cancer Biology,)

  • Jynho Kim

    (Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, California 94305, USA)

  • John P. Chute

    (Duke University Medical Center, Durham, North Carolina 27710, USA)

  • David Rizzieri

    (Duke University Medical Center, Durham, North Carolina 27710, USA)

  • Michael Munchhof

    (Pfizer Laboratories, Groton, Connecticut 06340, USA)

  • Todd VanArsdale

    (Pfizer Laboratories, La Jolla, California 92121, USA)

  • Philip A. Beachy

    (Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, California 94305, USA)

  • Tannishtha Reya

    (Department of Pharmacology and Cancer Biology,)

Abstract

Hedgehog maintains cancer stem cells Hedgehog signalling has been implicated in a number of cancers. It is now shown to be important in chronic myeloid leukaemias (CML) where it acts to maintain leukaemia stem cells, by regulating the expression of Numb. Importantly, CML stem cells can be depleted when Hedgehog signalling is inhibited, including cells that are resistant to the drug imatinib that is used to treat CML.

Suggested Citation

  • Chen Zhao & Alan Chen & Catriona H. Jamieson & Mark Fereshteh & Annelie Abrahamsson & Jordan Blum & Hyog Young Kwon & Jynho Kim & John P. Chute & David Rizzieri & Michael Munchhof & Todd VanArsdale & , 2009. "Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia," Nature, Nature, vol. 458(7239), pages 776-779, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7239:d:10.1038_nature07737
    DOI: 10.1038/nature07737
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