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Zhou et al. reply

Author

Listed:
  • Zhifeng Zhou

    (Laboratory of Neurogenetics, NIAAA, NIH)

  • Guanshan Zhu

    (Laboratory of Neurogenetics, NIAAA, NIH)

  • Ahmad R. Hariri

    (Human Genetics, and Psychology, University of Pittsburgh)

  • Mary-Anne Enoch

    (Laboratory of Neurogenetics, NIAAA, NIH)

  • David Scott

    (University of Michigan Medical School)

  • Rajita Sinha

    (Yale University School of Medicine)

  • Matti Virkkunen

    (University of Helsinki)

  • Deborah C. Mash

    (University of Miami School of Medicine)

  • Robert H. Lipsky

    (Laboratory of Neurogenetics, NIAAA, NIH)

  • Xian-Zhang Hu

    (Laboratory of Neurogenetics, NIAAA, NIH)

  • Colin A. Hodgkinson

    (Laboratory of Neurogenetics, NIAAA, NIH)

  • Ke Xu

    (Laboratory of Neurogenetics, NIAAA, NIH)

  • Beata Buzas

    (Laboratory of Neurogenetics, NIAAA, NIH)

  • Qiaoping Yuan

    (Laboratory of Neurogenetics, NIAAA, NIH)

  • Pei-Hong Shen

    (Laboratory of Neurogenetics, NIAAA, NIH)

  • Robert E. Ferrell

    (Human Genetics, and Psychology, University of Pittsburgh)

  • Stephen B. Manuck

    (Human Genetics, and Psychology, University of Pittsburgh)

  • Sarah M. Brown

    (Human Genetics, and Psychology, University of Pittsburgh)

  • Richard L. Hauger

    (San Diego VA Healthcare System and University of California)

  • Christian S. Stohler

    (School of Dentistry, University of Maryland)

  • Jon-Kar Zubieta

    (University of Michigan Medical School)

  • David Goldman

    (Laboratory of Neurogenetics, NIAAA, NIH)

Abstract

Replying to: C. H. Cotton, J. Flint & T. G. Campbell Nature 458, 10.1038/nature07927 (2009) The inability of Cotton et al. 1 to detect an effect of a functional haplotype (and locus) of neuropeptide Y (NPY), a stress regulatory neuropeptide, on neuroticism is interesting. Although it is important to measure effects of functional loci on complex behaviours, the strength of our study2, and primary basis of its conclusions, was the larger and convergent effects of NPY on intermediate phenotypes, including regional brain responses to emotional stimuli and pain, and brain NPY messenger RNA and plasma NPY levels. Eysenck Neuroticism is a trait that we did not directly investigate. We reported modest association of NPY with two Harm Avoidance subscales from the Tridimensional Personality Questionnaire. Association of NPY with the complex trait of anxiety, especially when measured differently, is not the first place we would look to validate our results.

Suggested Citation

  • Zhifeng Zhou & Guanshan Zhu & Ahmad R. Hariri & Mary-Anne Enoch & David Scott & Rajita Sinha & Matti Virkkunen & Deborah C. Mash & Robert H. Lipsky & Xian-Zhang Hu & Colin A. Hodgkinson & Ke Xu & Beat, 2009. "Zhou et al. reply," Nature, Nature, vol. 458(7238), pages 7-7, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7238:d:10.1038_nature07928
    DOI: 10.1038/nature07928
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