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An unexpected twist in viral capsid maturation

Author

Listed:
  • Ilya Gertsman

    (The Scripps Research Institute, La Jolla, California 92037, USA
    University of California San Diego, La Jolla, California 92037, USA)

  • Lu Gan

    (The Scripps Research Institute, La Jolla, California 92037, USA
    Present address: Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.)

  • Miklos Guttman

    (University of California San Diego, La Jolla, California 92037, USA)

  • Kelly Lee

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Jeffrey A. Speir

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Robert L. Duda

    (University of Pittsburgh, Pennsylvania 15260, USA)

  • Roger W. Hendrix

    (University of Pittsburgh, Pennsylvania 15260, USA)

  • Elizabeth A. Komives

    (University of California San Diego, La Jolla, California 92037, USA)

  • John E. Johnson

    (The Scripps Research Institute, La Jolla, California 92037, USA
    University of California San Diego, La Jolla, California 92037, USA)

Abstract

Viral procapsid structure The lambda-like double-stranded (ds) DNA bacteriophage HK97 is a favourable system for studying viral capsid maturation since it can be assembled in Escherichia coli from the expression of just two viral gene products and maturation is easily triggered and analysed in vitro. Various mature viral capsid structures have been determined but until now no procapsids have been available for a dsDNA virus or bacteriophage. Gertsman et al. now report the high-resolution structure of the HK97 procapsid providing insight into the capsid assembly process leading to infectious virions. The knowledge gained from this structure is relevant for related viruses such as the human herpesvirus.

Suggested Citation

  • Ilya Gertsman & Lu Gan & Miklos Guttman & Kelly Lee & Jeffrey A. Speir & Robert L. Duda & Roger W. Hendrix & Elizabeth A. Komives & John E. Johnson, 2009. "An unexpected twist in viral capsid maturation," Nature, Nature, vol. 458(7238), pages 646-650, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7238:d:10.1038_nature07686
    DOI: 10.1038/nature07686
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