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Dynamic expression of epidermal caspase 8 simulates a wound healing response

Author

Listed:
  • Pedro Lee

    (Section of Cell and Developmental Biology, Natural Science Building, Room 6311, 9500 Gilman Drive, MC 0380)

  • Dai-Jen Lee

    (Section of Cell and Developmental Biology, Natural Science Building, Room 6311, 9500 Gilman Drive, MC 0380)

  • Carol Chan

    (Section of Cell and Developmental Biology, Natural Science Building, Room 6311, 9500 Gilman Drive, MC 0380)

  • Shih-Wei Chen

    (Section of Cell and Developmental Biology, Natural Science Building, Room 6311, 9500 Gilman Drive, MC 0380)

  • Irene Ch’en

    (Section of Molecular Biology, Natural Science Building, Room 5116, 9500 Gilman Drive, MC 0377)

  • Colin Jamora

    (Section of Cell and Developmental Biology, Natural Science Building, Room 6311, 9500 Gilman Drive, MC 0380
    Natural Science Building, Room 6113, 9500 Gilman Drive, MC 0380, La Jolla, California 92093, USA)

Abstract

Caspase 8: healing versus neoplasia This paper provides evidence for a role of caspase 8 in skin homeostasis. Loss of epidermal caspase 8, an important mediator of apoptosis, promotes several phases of the wound healing response in mice, including epidermal cell proliferation and inflammation. The findings illustrate how the loss of caspase 8 can have an impact beyond programmed cell death to affect the local microenvironment and elicit processes common to wound repair and many neoplastic skin disorders.

Suggested Citation

  • Pedro Lee & Dai-Jen Lee & Carol Chan & Shih-Wei Chen & Irene Ch’en & Colin Jamora, 2009. "Dynamic expression of epidermal caspase 8 simulates a wound healing response," Nature, Nature, vol. 458(7237), pages 519-523, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7237:d:10.1038_nature07687
    DOI: 10.1038/nature07687
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