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Genetic architecture of mouse skin inflammation and tumour susceptibility

Author

Listed:
  • David A. Quigley

    (Helen Diller Family Comprehensive Cancer Center,)

  • Minh D. To

    (Helen Diller Family Comprehensive Cancer Center,
    University of California San Francisco, San Francisco, California 94115, USA)

  • Jesús Pérez-Losada

    (Facultad de Medicina, Universidad de Salamanca, Campus Miguel de Unamuno s/n)

  • Facundo G. Pelorosso

    (Helen Diller Family Comprehensive Cancer Center,)

  • Jian-Hua Mao

    (Helen Diller Family Comprehensive Cancer Center,
    Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA)

  • Hiroki Nagase

    (Advanced Research Institute for the Sciences and Humanities, Nihon University
    Roswell Park Cancer Institute, Buffalo, New York 14263, USA)

  • David G. Ginzinger

    (Helen Diller Family Comprehensive Cancer Center,)

  • Allan Balmain

    (Helen Diller Family Comprehensive Cancer Center,)

Abstract

Susceptibility to skin cancer Systems genetics approaches are beginning to reveal how inherited genetic variants affect the structure and function of normal tissues, as well as individual susceptibility to diseases. A systems genetics study of skin tumour incidence, using crosses between two strains of mice one of which is susceptible and the other resistant to tumour development, has now been used to map genetic variants that contribute to skin cancer susceptibility. A comparison of gene expression in mutant mice with that in normal skin identifies gene expression motifs that contribute to tissue organization and various biological functions; key features emerging are a candidate master regulator of hair follicle fate, and a regulator of coordinated control of epidermal barrier function, inflammation and tumour susceptibility.

Suggested Citation

  • David A. Quigley & Minh D. To & Jesús Pérez-Losada & Facundo G. Pelorosso & Jian-Hua Mao & Hiroki Nagase & David G. Ginzinger & Allan Balmain, 2009. "Genetic architecture of mouse skin inflammation and tumour susceptibility," Nature, Nature, vol. 458(7237), pages 505-508, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7237:d:10.1038_nature07683
    DOI: 10.1038/nature07683
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