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A burst of segmental duplications in the genome of the African great ape ancestor

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Listed:
  • Tomas Marques-Bonet

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA
    Institut de Biologia Evolutiva (UPF-CSIC), 08003 Barcelona, Catalonia, Spain)

  • Jeffrey M. Kidd

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA)

  • Mario Ventura

    (University of Bari)

  • Tina A. Graves

    (Genome Sequencing Center, Washington University School of Medicine, St Louis, Missouri 63108, USA)

  • Ze Cheng

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA)

  • LaDeana W. Hillier

    (Genome Sequencing Center, Washington University School of Medicine, St Louis, Missouri 63108, USA)

  • Zhaoshi Jiang

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA)

  • Carl Baker

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA)

  • Ray Malfavon-Borja

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA)

  • Lucinda A. Fulton

    (Genome Sequencing Center, Washington University School of Medicine, St Louis, Missouri 63108, USA)

  • Can Alkan

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA)

  • Gozde Aksay

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA)

  • Santhosh Girirajan

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA)

  • Priscillia Siswara

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA)

  • Lin Chen

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA)

  • Maria Francesca Cardone

    (University of Bari)

  • Arcadi Navarro

    (Institut de Biologia Evolutiva (UPF-CSIC), 08003 Barcelona, Catalonia, Spain
    Institució Catalana de Recerca i Estudis Avançats (ICREA) and Instituto Nacional de Bioinformática (INB), Dr. Aiguader 88, 08003 Barcelona, Spain)

  • Elaine R. Mardis

    (Genome Sequencing Center, Washington University School of Medicine, St Louis, Missouri 63108, USA)

  • Richard K. Wilson

    (Genome Sequencing Center, Washington University School of Medicine, St Louis, Missouri 63108, USA)

  • Evan E. Eichler

    (University of Washington and the Howard Hughes Medical Institute, Seattle, Washington 98195, USA)

Abstract

Primate genomes: going ape With four primate genome sequences now available — macaque, orang-utan, chimpanzee and human — it has become possible to construct a comparative segmental duplication map of four primate genomes. This has now been done, and the resulting map used to reconstruct the evolutionary history of all human segmental duplications. The ancestral branch leading to humans and the African great apes shows a fourfold acceleration of segmental duplication accumulation at a time when other mutational processes such as single-base-pair mutation were slowing. This apparent burst of activity may be the result of a change in the effective population size or generation time, or imply a period of genomic destabilization.

Suggested Citation

  • Tomas Marques-Bonet & Jeffrey M. Kidd & Mario Ventura & Tina A. Graves & Ze Cheng & LaDeana W. Hillier & Zhaoshi Jiang & Carl Baker & Ray Malfavon-Borja & Lucinda A. Fulton & Can Alkan & Gozde Aksay &, 2009. "A burst of segmental duplications in the genome of the African great ape ancestor," Nature, Nature, vol. 457(7231), pages 877-881, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7231:d:10.1038_nature07744
    DOI: 10.1038/nature07744
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