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Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80

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Listed:
  • Boxun Lu

    (University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA)

  • Yanhua Su

    (University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA
    Present address: State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China.)

  • Sudipto Das

    (University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA)

  • Haikun Wang

    (University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA)

  • Yan Wang

    (University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA)

  • Jin Liu

    (University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA)

  • Dejian Ren

    (University of Pennsylvania, 415 S. University Avenue, Philadelphia, Pennsylvania 19104, USA)

Abstract

Neuropetides: action via NALCN and UNC-80 Substance P is a neuropeptide that evokes slow excitation following activation of its cognate G-protein-coupled receptor. Lu et al. investigate the downstream pathway of substance P and show that it depends on Src family kinases rather than G-protein signalling. They also identify the target ion channel as the NALCN cation channel, which acts in complex with a cytosolic protein of unknown function, UNC-80.

Suggested Citation

  • Boxun Lu & Yanhua Su & Sudipto Das & Haikun Wang & Yan Wang & Jin Liu & Dejian Ren, 2009. "Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80," Nature, Nature, vol. 457(7230), pages 741-744, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7230:d:10.1038_nature07579
    DOI: 10.1038/nature07579
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