IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v457y2009i7230d10.1038_nature07578.html
   My bibliography  Save this article

Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction

Author

Listed:
  • Dagmar Heuer

    (Department of Molecular Biology,)

  • Anette Rejman Lipinski

    (Department of Molecular Biology,)

  • Nikolaus Machuy

    (Department of Molecular Biology,)

  • Alexander Karlas

    (Department of Molecular Biology,)

  • Andrea Wehrens

    (Department of Molecular Biology,)

  • Frank Siedler

    (Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany)

  • Volker Brinkmann

    (Microscopy Core Facility, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany)

  • Thomas F. Meyer

    (Department of Molecular Biology,)

Abstract

Golgi bodies hijacked Like many other intracellular pathogens Chlamydia trachomatis depends on host lipids for growth. A mechanism by which Chlamydia can acquire its lipids has now been demonstrated in infected HeLa epithelial cells. In the normal cell the Golgi apparatus acts to modify newly synthesized proteins and lipids for distribution within or outside the cell. The intracellular replication of C. trachomatis triggers the breakdown of the Golgi apparatus to generate functionally intact Golgi ministacks via cleavage of the matrix protein golgin-84. The Golgi ministacks, which align around the bacterial inclusion, appear to provide a conduit through which the pathogen can secure a supply of lipids. This work points to mechanistic involvement of inflammatory caspases and calpains, which may be used as novel molecular targets for antichlamydial agents.

Suggested Citation

  • Dagmar Heuer & Anette Rejman Lipinski & Nikolaus Machuy & Alexander Karlas & Andrea Wehrens & Frank Siedler & Volker Brinkmann & Thomas F. Meyer, 2009. "Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction," Nature, Nature, vol. 457(7230), pages 731-735, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7230:d:10.1038_nature07578
    DOI: 10.1038/nature07578
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07578
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07578?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:457:y:2009:i:7230:d:10.1038_nature07578. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.