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Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells

Author

Listed:
  • Koushik Roy

    (Department of Medicine,)

  • George M. Hilliard

    (Department of Molecular Sciences,)

  • David J. Hamilton

    (University of Tennessee Health Science Center, 956 Court Avenue, Memphis, Tennessee 38163, Tennessee, USA)

  • Jiwen Luo

    (Department of Medicine,)

  • Marguerite M. Ostmann

    (Research Service,)

  • James M. Fleckenstein

    (Department of Medicine,
    Department of Molecular Sciences,
    Medicine Service, Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, Tennessee 38104, USA)

Abstract

E. coli vaccine targets Enterotoxigenic Escherichia coli is the most common cause of diarrhoea in developing countries and is the principal cause of traveller's diarrhoea. Adhesion to host cells is essential for the virulence of this and many other bacterial pathogens. A new adhesion mechanism has been identified in E. coli that relies on the secreted protein EtpA. The protein interacts with conserved regions of flagellin molecules at the tips of the bacterial flagella where it forms an adhesive molecular bridge between the bacterium and the host cell. This finding adds to the evidence that EtpA — and the conserved flagellin ligands —could be viable antigenic targets for vaccines against E. coli and other motile pathogens.

Suggested Citation

  • Koushik Roy & George M. Hilliard & David J. Hamilton & Jiwen Luo & Marguerite M. Ostmann & James M. Fleckenstein, 2009. "Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells," Nature, Nature, vol. 457(7229), pages 594-598, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7229:d:10.1038_nature07568
    DOI: 10.1038/nature07568
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