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Endochondral ossification is required for haematopoietic stem-cell niche formation

Author

Listed:
  • Charles K. F. Chan

    (Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA)

  • Ching-Cheng Chen

    (Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA)

  • Cynthia A. Luppen

    (Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA)

  • Jae-Beom Kim

    (Stanford University, California, USA
    Present address: Caliper Life Sciences, 2061 Challenger Drive, Alameda, California 94501, USA.)

  • Anthony T. DeBoer

    (Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA)

  • Kevin Wei

    (Stanford University, California, USA)

  • Jill A. Helms

    (Stanford University, California, USA)

  • Calvin J. Kuo

    (Stanford University, California, USA)

  • Daniel L. Kraft

    (Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA)

  • Irving L. Weissman

    (Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA)

Abstract

Haematopoietic stem cells: establishing a niche Chan et al. identify and prospectively isolate a progenitor cell population derived from mouse fetal limb skeletal elements that forms an ectopic haematopoietic stem cell (HSC) niche in vivo. When transplanted under the adult mouse kidney capsule, the cells recruit host-derived blood vessels, produce donor-derived ectopic bones, and generate a marrow cavity populated by host-derived long-term reconstituting HSCs. Niche generation was inhibited by the suppression of factors involved in endochondral ossification.

Suggested Citation

  • Charles K. F. Chan & Ching-Cheng Chen & Cynthia A. Luppen & Jae-Beom Kim & Anthony T. DeBoer & Kevin Wei & Jill A. Helms & Calvin J. Kuo & Daniel L. Kraft & Irving L. Weissman, 2009. "Endochondral ossification is required for haematopoietic stem-cell niche formation," Nature, Nature, vol. 457(7228), pages 490-494, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7228:d:10.1038_nature07547
    DOI: 10.1038/nature07547
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