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Transcription inactivation through local refolding of the RNA polymerase structure

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Listed:
  • Georgiy A. Belogurov

    (The Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA)

  • Marina N. Vassylyeva

    (University of Alabama at Birmingham, Schools of Medicine and Dentistry, 720 20th Street South, Birmingham, Alabama 35294, USA)

  • Anastasiya Sevostyanova

    (The Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA)

  • James R. Appleman

    (Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, California 92121, USA)

  • Alan X. Xiang

    (Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, California 92121, USA)

  • Ricardo Lira

    (Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, California 92121, USA)

  • Stephen E. Webber

    (Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, California 92121, USA)

  • Sergiy Klyuyev

    (University of Alabama at Birmingham, Schools of Medicine and Dentistry, 720 20th Street South, Birmingham, Alabama 35294, USA)

  • Evgeny Nudler

    (New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA)

  • Irina Artsimovitch

    (The Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA)

  • Dmitry G. Vassylyev

    (University of Alabama at Birmingham, Schools of Medicine and Dentistry, 720 20th Street South, Birmingham, Alabama 35294, USA)

Abstract

Myxopyronins on target A crystal structure of the antibiotic myxopyronin bound to bacterial RNA polymerase (RNAP) reveals insights into how the antibiotic targets the formation of the pre-catalytic transcription initiation complex and the mechanism of open complex formation. The myxopyronins are possibly the first structurally characterized class of antibiotics known to act on this decisive step in gene expression control.

Suggested Citation

  • Georgiy A. Belogurov & Marina N. Vassylyeva & Anastasiya Sevostyanova & James R. Appleman & Alan X. Xiang & Ricardo Lira & Stephen E. Webber & Sergiy Klyuyev & Evgeny Nudler & Irina Artsimovitch & Dmi, 2009. "Transcription inactivation through local refolding of the RNA polymerase structure," Nature, Nature, vol. 457(7227), pages 332-335, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7227:d:10.1038_nature07510
    DOI: 10.1038/nature07510
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