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Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

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  • Sandra Rebouissou

    (Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France
    Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie)

  • Mohamed Amessou

    (Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France
    Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie)

  • Gabrielle Couchy

    (Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France
    Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie)

  • Karine Poussin

    (Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France
    Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie)

  • Sandrine Imbeaud

    (Array s/IMAGE, Genexpress, Functional Genomics and Systems Biology for Health, UMR 7091 CNRS; Université Paris 6 Pierre et Marie Curie
    Gif/Orsay DNA Microarray Platform (GODMAP), Centre de Génétique Moléculaire, UPR 2167 CNRS; Université Paris-Sud 11)

  • Camilla Pilati

    (Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France
    Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie)

  • Tina Izard

    (The Scripps Research Institute, Jupiter, Florida 33458, USA)

  • Charles Balabaud

    (Inserm, U889; Université Victor Segalen Bordeaux 2, IFR66, Bordeaux F-33076, France
    Université Victor Segalen Bordeaux 2, IFR66, Bordeaux F-33076, France
    CHU de Bordeaux, Hôpital Saint-André, Service d’hépatologie, Bordeaux F-33076, France)

  • Paulette Bioulac-Sage

    (Inserm, U889; Université Victor Segalen Bordeaux 2, IFR66, Bordeaux F-33076, France
    Université Victor Segalen Bordeaux 2, IFR66, Bordeaux F-33076, France
    CHU de Bordeaux, Hôpital Pellegrin, Service d’Anatomie Pathologique, Bordeaux F-33076, France)

  • Jessica Zucman-Rossi

    (Inserm, U674, Génomique fonctionnelle des tumeurs solides, Paris F-75010, France
    Université Paris Diderot, Paris 7, Institut Universitaire d’Hématologie)

Abstract

Inflammation and cancer It is know that there is a link between some types of chronic inflammation and certain cancers. Now a genetic study of liver tumour tissues has identified gain-of-function mutations in the IL6ST gene, part of an inflammatory signalling pathway that codes for the interleukin-6 co-receptor gp130, as a possible early step on the development of benign liver tumours. This mutation in IL6ST was frequently found together with mutations in β-catenin, suggesting that they may cooperate in promoting tumorigenesis.

Suggested Citation

  • Sandra Rebouissou & Mohamed Amessou & Gabrielle Couchy & Karine Poussin & Sandrine Imbeaud & Camilla Pilati & Tina Izard & Charles Balabaud & Paulette Bioulac-Sage & Jessica Zucman-Rossi, 2009. "Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours," Nature, Nature, vol. 457(7226), pages 200-204, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7226:d:10.1038_nature07475
    DOI: 10.1038/nature07475
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