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Detection of functional haematopoietic stem cell niche using real-time imaging

Author

Listed:
  • Yucai Xie

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
    Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197, Rui Jin 2 Road, Shanghai 200025, China)

  • Tong Yin

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Winfried Wiegraebe

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Xi C. He

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Diana Miller

    (and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA)

  • Danny Stark

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Katherine Perko

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Richard Alexander

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Joel Schwartz

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Justin C. Grindley

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Jungeun Park

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Jeff S. Haug

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Joshua P. Wunderlich

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Hua Li

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Simon Zhang

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Teri Johnson

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA)

  • Ricardo A. Feldman

    (and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA)

  • Linheng Li

    (Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, Missouri 64110, USA
    Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA)

Abstract

A bone-marrow niche Haematopoietic stem cells are found in a specialized regulatory environment or niche in bone marrow. The precise location and characteristics of this niche are now made clearer by two sophisticated imaging studies. Lo Celso et al. performed live-animal tracking of individual haematopoietic cells and find that osteoblasts are enmeshed in microvessels and that different haematopoietic cell populations are localized in different areas according to their stage of differentiation. Xie et al. used newly developed ex vivo real-time imaging technology and immunoassays to trace the homing of fluorescently labelled haematopoietic stem cells in response to irradiation. They report that the membrane lining the medullary cavity of bone forms a special zone that normally maintains haematopoietic stem cells, but promotes their expansion in response to bone marrow damage.

Suggested Citation

  • Yucai Xie & Tong Yin & Winfried Wiegraebe & Xi C. He & Diana Miller & Danny Stark & Katherine Perko & Richard Alexander & Joel Schwartz & Justin C. Grindley & Jungeun Park & Jeff S. Haug & Joshua P. W, 2009. "Detection of functional haematopoietic stem cell niche using real-time imaging," Nature, Nature, vol. 457(7225), pages 97-101, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7225:d:10.1038_nature07639
    DOI: 10.1038/nature07639
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