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Structural recognition and functional activation of FcγR by innate pentraxins

Author

Listed:
  • Jinghua Lu

    (Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA)

  • Lorraine L. Marnell

    (University of New Mexico, Albuquerque, New Mexico 87131, USA)

  • Kristopher D. Marjon

    (University of New Mexico, Albuquerque, New Mexico 87131, USA)

  • Carolyn Mold

    (University of New Mexico, Albuquerque, New Mexico 87131, USA)

  • Terry W. Du Clos

    (University of New Mexico, Albuquerque, New Mexico 87131, USA
    VA Medical Center, Albuquerque, New Mexico 87108, USA)

  • Peter D. Sun

    (Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA)

Abstract

Pentraxins involved in FcγR activation The classical pentraxins, serum amyloid P component (SAP) and C-reactive protein (CRP), are major acute phase reactants in mouse and man. As shown in this paper, pentraxins recognize various FcγRs, and SAP opsonization activates FcγR-mediated phagocytosis and cytokine secretion. The receptor binding sites for SAP and IgG overlap resulting in competition of IgG binding to FcγR as well as inhibition of immune complex-mediated phagocytosis by soluble pentraxins.

Suggested Citation

  • Jinghua Lu & Lorraine L. Marnell & Kristopher D. Marjon & Carolyn Mold & Terry W. Du Clos & Peter D. Sun, 2008. "Structural recognition and functional activation of FcγR by innate pentraxins," Nature, Nature, vol. 456(7224), pages 989-992, December.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7224:d:10.1038_nature07468
    DOI: 10.1038/nature07468
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