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G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling

Author

Listed:
  • Stacey K. Ogden

    (Department of Pharmacology and Toxicology,)

  • Dennis Liang Fei

    (Department of Pharmacology and Toxicology,)

  • Neal S. Schilling

    (Department of Pharmacology and Toxicology,)

  • Yashi F. Ahmed

    (Department of Genetics,
    Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA)

  • John Hwa

    (Department of Pharmacology and Toxicology,
    Dartmouth Medical School, Hanover, New Hampshire 03755, USA)

  • David J. Robbins

    (Department of Pharmacology and Toxicology,
    Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA)

Abstract

Hedgehog signalling: the role of G proteins Whether G proteins might play a role in Hedgehog (Hh) signal transduction has been controversial. Here, the seven-domain transmembrane protein Smoothened (Smo) is shown to activate a G protein, Gαi, to modulate intracellular cyclic AMP levels in response to Hh.

Suggested Citation

  • Stacey K. Ogden & Dennis Liang Fei & Neal S. Schilling & Yashi F. Ahmed & John Hwa & David J. Robbins, 2008. "G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling," Nature, Nature, vol. 456(7224), pages 967-970, December.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7224:d:10.1038_nature07459
    DOI: 10.1038/nature07459
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