IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v456y2008i7224d10.1038_nature07444.html
   My bibliography  Save this article

X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus

Author

Listed:
  • Zachary A. Bornholdt

    (Department of Molecular Virology and Microbiology,)

  • B. V. Venkataram Prasad

    (Department of Molecular Virology and Microbiology,
    Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

Abstract

Avian flu virulence The NS1 protein of influenza virus is a critical virulence factor that antagonizes the host antiviral response by multiple mechanisms, including the binding and sequestration of double-stranded RNA. The structure of full-length NS1 protein has now been determined using samples from a virulent H5N1 avian influenza virus strain isolated during a 2004 Vietnamese 'bird flu' outbreak. The molecule's RNA binding domain shows subtle differences when compared to that in non-H5N1 strains whereas the effector domain is significantly altered. The two domains interact in such a way as to form tubules that may act to sequester dsRNA, allowing the virus to evade the host's innate immune response.

Suggested Citation

  • Zachary A. Bornholdt & B. V. Venkataram Prasad, 2008. "X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus," Nature, Nature, vol. 456(7224), pages 985-988, December.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7224:d:10.1038_nature07444
    DOI: 10.1038/nature07444
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07444
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07444?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:456:y:2008:i:7224:d:10.1038_nature07444. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.