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Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen

Author

Listed:
  • Antoni Hurtado

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Kelly A. Holmes

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Timothy R. Geistlinger

    (Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA)

  • Iain R. Hutcheson

    (Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University)

  • Robert I. Nicholson

    (Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University)

  • Myles Brown

    (Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA)

  • Jie Jiang

    (Imperial College London, Hammersmith Hospital)

  • William J. Howat

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Simak Ali

    (Imperial College London, Hammersmith Hospital)

  • Jason S. Carroll

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

Abstract

Tamoxifen resistance mechanism Tamoxifen is commonly used for breast cancer therapy, but a proportion of patients become resistant to the treatment, and their cancer is more likely to return. A study of the relationship between the oestrogen receptor and ERBB2/HER-2 pathways in breast cancer throws light on the mechanism of tamoxifen action and on the basis of tamoxifen-resistance. The new work shows that Pax2 is required for active repression of ErbB2 in breast cancer and that reduction of Pax2 causes ErbB2-driven tamoxifen-resistant cell growth.

Suggested Citation

  • Antoni Hurtado & Kelly A. Holmes & Timothy R. Geistlinger & Iain R. Hutcheson & Robert I. Nicholson & Myles Brown & Jie Jiang & William J. Howat & Simak Ali & Jason S. Carroll, 2008. "Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen," Nature, Nature, vol. 456(7222), pages 663-666, December.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7222:d:10.1038_nature07483
    DOI: 10.1038/nature07483
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