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Sox18 induces development of the lymphatic vasculature in mice

Author

Listed:
  • Mathias François

    (Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia)

  • Andrea Caprini

    (IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy)

  • Brett Hosking

    (Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia)

  • Fabrizio Orsenigo

    (IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy)

  • Dagmar Wilhelm

    (Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia)

  • Catherine Browne

    (Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia)

  • Karri Paavonen

    (Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital)

  • Tara Karnezis

    (Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital)

  • Ramin Shayan

    (Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital
    The University of Melbourne, Parkville, Victoria 3052, Australia)

  • Meredith Downes

    (Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia)

  • Tara Davidson

    (Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia)

  • Desmond Tutt

    (Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia)

  • Kathryn S. E. Cheah

    (Development & Growth, University of Hong Kong, Pokfulam, Hong Kong, China)

  • Steven A. Stacker

    (Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital)

  • George E. O. Muscat

    (Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia)

  • Marc G. Achen

    (Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital)

  • Elisabetta Dejana

    (IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    University of Milan)

  • Peter Koopman

    (Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia)

Abstract

Sox18 as a lymphatic switch Mutations in the Sox18 transcription factor gene cause lymphatic dysfunction in the rare human syndrome hypotrichosis-lymphoedema-telangiectasia, suggesting that it may play a role in lymphatic development of function. That role has now been identified: Sox18 acts as a molecular switch to induce differentiation of lymphatic endothelial cells via the direct activation of transcription of the Prox1 lymphatic marker in lymphatic precursor cells of the embryonic venous system. This suggests possible new strategies for therapeutic stimulation or suppression of lymphoangiogenesis.

Suggested Citation

  • Mathias François & Andrea Caprini & Brett Hosking & Fabrizio Orsenigo & Dagmar Wilhelm & Catherine Browne & Karri Paavonen & Tara Karnezis & Ramin Shayan & Meredith Downes & Tara Davidson & Desmond Tu, 2008. "Sox18 induces development of the lymphatic vasculature in mice," Nature, Nature, vol. 456(7222), pages 643-647, December.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7222:d:10.1038_nature07391
    DOI: 10.1038/nature07391
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