IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v456y2008i7221d10.1038_nature07476.html
   My bibliography  Save this article

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

Author

Listed:
  • Simone Difilippantonio

    (Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1360, USA)

  • Eric Gapud

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

  • Nancy Wong

    (Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1360, USA)

  • Ching-Yu Huang

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

  • Grace Mahowald

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

  • Hua Tang Chen

    (Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1360, USA)

  • Michael J. Kruhlak

    (Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1360, USA)

  • Elsa Callen

    (Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1360, USA)

  • Ferenc Livak

    (University of Maryland School of Medicine, Baltimore, Maryland 21201, USA)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology, The Rockefeller University and Howard Hughes Medical Institute, New York, New York 10021, USA)

  • Barry P. Sleckman

    (Washington University School of Medicine, St Louis, Missouri 63110, USA)

  • André Nussenzweig

    (Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1360, USA)

Abstract

DNA repair: 53BP1 puts ends in motion When either exogenous or endogenous double-strand breaks occur, the p53 binding protein 53BP1 is one of the earliest proteins to be recruited to the site of the break. 53BP1 helps to promote rejoining of DNA ends during class switch recombination; in a pair of papers in this week's Nature, the laboratories of André Nussenzweig and Titia de Lange show it is also required for V(D)J recombination and for joining of DNA breaks in telomeres. In V(D)J recombination, the ends of the programmed double-strand break are degraded when 53BP1 is absent, and joining between distal V and DJ segments is affected. At broken telomeres, 53BP1 increases the volume of the nucleus searched by the DNA ends so that they are more likely to encounter a partner to which they can be ligated. Thus, 53BP1 facilitates repair by changing the dynamics of movement of broken ends, making long-range interactions more frequent.

Suggested Citation

  • Simone Difilippantonio & Eric Gapud & Nancy Wong & Ching-Yu Huang & Grace Mahowald & Hua Tang Chen & Michael J. Kruhlak & Elsa Callen & Ferenc Livak & Michel C. Nussenzweig & Barry P. Sleckman & André, 2008. "53BP1 facilitates long-range DNA end-joining during V(D)J recombination," Nature, Nature, vol. 456(7221), pages 529-533, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7221:d:10.1038_nature07476
    DOI: 10.1038/nature07476
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07476
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07476?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:456:y:2008:i:7221:d:10.1038_nature07476. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.