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Sarcolemma-localized nNOS is required to maintain activity after mild exercise

Author

Listed:
  • Yvonne M. Kobayashi

    (Howard Hughes Medical Institute,
    Department of Molecular Physiology and Biophysics,
    Department of Neurology,
    Department of Internal Medicine,)

  • Erik P. Rader

    (Howard Hughes Medical Institute,
    Department of Molecular Physiology and Biophysics,
    Department of Neurology,
    Department of Internal Medicine,)

  • Robert W. Crawford

    (Howard Hughes Medical Institute,
    Department of Molecular Physiology and Biophysics,
    Department of Neurology,
    Department of Internal Medicine,)

  • Nikhil K. Iyengar

    (Department of Internal Medicine,)

  • Daniel R. Thedens

    (Department of Radiology,)

  • John A. Faulkner

    (University of Michigan, 2031 Biomedical Sciences Research Building, Ann Arbor, Michigan 48109-2200, USA)

  • Swapnesh V. Parikh

    (Department of Internal Medicine,)

  • Robert M. Weiss

    (Department of Internal Medicine,)

  • Jeffrey S. Chamberlain

    (University of Washington School of Medicine, HSB, Room K243b, Seattle, Washington 98195-7720, USA)

  • Steven A. Moore

    (University of Iowa, Roy J. and Lucille A. Carver College of Medicine, 4283 Carver Biomedical Research Building, 285 Newton Road, Iowa City, Iowa 52242-1101, USA)

  • Kevin P. Campbell

    (Howard Hughes Medical Institute,
    Department of Molecular Physiology and Biophysics,
    Department of Neurology,
    Department of Internal Medicine,)

Abstract

Signalling muscle fatigue Many neuromuscular conditions, such as Duchenne muscular dystrophy, involve an exaggerated exercise-induced fatigue response. Experiments in mice have identified a potential cause of this fatigue: when neuronal nitric oxide synthase (nNOS) is missing from its normal location on the muscle membrane, the blood vessels that supply the muscles fail to relax normally and the animals experience post-exercise fatigue. Sarcolemmal nNOS was found to be reduced in biopsies from patients with a range of distinct myopathies pointing towards a common mechanism of fatigue. These results suggest that patients with an exaggerated fatigue response to mild exercise may respond to treatment that improves exercise-induced signalling.

Suggested Citation

  • Yvonne M. Kobayashi & Erik P. Rader & Robert W. Crawford & Nikhil K. Iyengar & Daniel R. Thedens & John A. Faulkner & Swapnesh V. Parikh & Robert M. Weiss & Jeffrey S. Chamberlain & Steven A. Moore & , 2008. "Sarcolemma-localized nNOS is required to maintain activity after mild exercise," Nature, Nature, vol. 456(7221), pages 511-515, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7221:d:10.1038_nature07414
    DOI: 10.1038/nature07414
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