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The ion pathway through the opened Na+,K+-ATPase pump

Author

Listed:
  • Ayako Takeuchi

    (Laboratory of Cardiac/Membrane Physiology, The Rockefeller University, New York, New York 10065, USA)

  • Nicolás Reyes

    (Laboratory of Cardiac/Membrane Physiology, The Rockefeller University, New York, New York 10065, USA)

  • Pablo Artigas

    (Laboratory of Cardiac/Membrane Physiology, The Rockefeller University, New York, New York 10065, USA)

  • David C. Gadsby

    (Laboratory of Cardiac/Membrane Physiology, The Rockefeller University, New York, New York 10065, USA)

Abstract

Open access: sodium and potassium ions in transit P-type ATPases are molecular machines that use energy derived from ATP hydrolysis to pump ions across membranes. Recent work on the Na+, K+ ATPase has identified a pathway for ions from the extracellular side of the protein to its ion binding sites. Here, Takeuchi et al. employ the marine toxin palytoxin to 'hold open' the gates of the pump, allowing direct measurements of ion flow. They define the entire route for ions from one side of the membrane to the other.

Suggested Citation

  • Ayako Takeuchi & Nicolás Reyes & Pablo Artigas & David C. Gadsby, 2008. "The ion pathway through the opened Na+,K+-ATPase pump," Nature, Nature, vol. 456(7220), pages 413-416, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7220:d:10.1038_nature07350
    DOI: 10.1038/nature07350
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