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Oligopotent stem cells are distributed throughout the mammalian ocular surface

Author

Listed:
  • François Majo

    (Laboratory of Stem Cell Dynamics,
    Department of Experimental Surgery Lausanne University Hospital (CHUV)
    Present address: Hôpital Ophtalmique Jules Gonin, Avenue de France 15, 1004 Lausanne CH, Switzerland.)

  • Ariane Rochat

    (Laboratory of Stem Cell Dynamics,
    Department of Experimental Surgery Lausanne University Hospital (CHUV))

  • Michael Nicolas

    (Laboratory of Stem Cell Dynamics,
    Department of Experimental Surgery Lausanne University Hospital (CHUV))

  • Georges Abou Jaoudé

    (Laboratory of Informatics and Visualization, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne CH, Switzerland)

  • Yann Barrandon

    (Laboratory of Stem Cell Dynamics,
    Department of Experimental Surgery Lausanne University Hospital (CHUV))

Abstract

Corneal stem cell niches It has been believed based on BrdU studies that the limbus is the niche for the stem cells responsible for the long-term renewal of the cornea. Majo et al. show instead that the renewal of the corneal epithelium is not different from other squamous epithelia, and is self-maintained without limbal contribution. The authors also show that the entire ocular surface of the pig, including the central cornea, contains stem cells that are oligopotent and can generate individual colonies of corneal and conjunctival cells. They propose that the limbus is not the sole niche for corneal stem cells.

Suggested Citation

  • François Majo & Ariane Rochat & Michael Nicolas & Georges Abou Jaoudé & Yann Barrandon, 2008. "Oligopotent stem cells are distributed throughout the mammalian ocular surface," Nature, Nature, vol. 456(7219), pages 250-254, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7219:d:10.1038_nature07406
    DOI: 10.1038/nature07406
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    Cited by:

    1. Stephen Iannaccone & Yue Zhou & David Walterhouse & Greg Taborn & Gabriel Landini & Philip Iannaccone, 2012. "Three Dimensional Visualization and Fractal Analysis of Mosaic Patches in Rat Chimeras: Cell Assortment in Liver, Adrenal Cortex and Cornea," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-14, February.

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